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forty eight These translocations may arise during the context of sophisticated karyo varieties. The commonest rearrangements require 13q14, with numerous partners, along with the IGH locus. The genes mostly rearranged with IGH are BCL2
It is important to think about the flow cytometry histograms to determine the depth of expression and whether or not the staining is “all, none, or partial.” The immunophenotype profile of basic CLL is dim sIg and dim CD20; CD5 and CD23 expression (not partial expression for possibly) is significant.
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